"All of creation cares not whether you live or die."
Kothysos was a realm destroyed by the Nephilim during their crusade across the realms under Absalom. The Second Kingdom had laid claim to the world and the demon force there inflicted the greatest loss of life upon the Nephilim before the battle of Eden, though they lost in the end.
The Nephilim lost two powerful weapons at Kothysos that were later recovered. The first was a potent sword named Affliction and the second was the Grand Abomination Earth Reaver.